| Abstract: | Semiquantitative morphological analysis of cerebral intraneuronal ubiquitin‐positive tau‐negative inclusions, a pathologic marker for motor neuron disease with dementia (MND‐D), was performed in the dentate gyrus and parahippocampal gyrus of 20 clinicopathologically confirmed patients with MND‐D. The forms of the inclusions were tentatively classified into three types: (i) C‐type, consisting of relatively large and intensely stained crescent or circular structures; (ii) L‐type, showing fine linear structures around the nuclei; and (iii) G‐type, showing faintly stained granular structures. The frequencies of the C‐type, L‐type and G‐type was 0.5–9.3%, 0.2–6.5% and 0–6.6% of dentate granule cells, respectively. In contrast to the dentate gyrus, almost all inclusions showed either the C‐type or L‐type form in the parahippocampal gyrus. A positive correlation was noted only between incidences of C‐type inclusion of the dentate gyrus and that of the parahippocampal gyrus (r = 0.69, P < 0.05). The morphological differences of the inclusions probably reflect different stages of their formation. |
