| 润肤剂对硫酸镍诱导皮肤ICAM-1表达的影响 |
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| 引用本文： | 陶赞英,凌月福,程培华.润肤剂对硫酸镍诱导皮肤ICAM-1表达的影响[J].华夏医学,2007,20(6):1193-1194. |
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| 作者姓名： | 陶赞英 凌月福 程培华 |
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| 作者单位： | 桂林医院院附属医院皮肤科,广西,桂林,541001;桂林医院院附属医院耳鼻喉-头颈外科,广西,桂林,541001 |
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| 摘 要： | 目的:研究润肤剂对硫酸镍(NiSO4)诱导的体外培养皮肤组织表皮ICAM-1表达的影响。方法:润肤剂组用润肤剂局部外用于皮肤表面,随后给予硫酸镍刺激48h;无润肤剂组用生理盐水代替润肤剂同法处理皮肤。免疫组织化学染色图像分析法检测ICAM-1的表达。结果:润肤剂组皮肤组织表皮ICAM-1表达明显较无润肤剂组低(P<0.05)。结论:润肤剂能显著减轻硫酸镍(NiSO4)诱导的体外培养皮肤组织表皮ICAM-1的表达。提示润肤剂对硫酸镍引起的接触性皮炎可能具有一定的保护作用。
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| 关 键 词： | 润肤剂 硫酸镍 细胞间粘附分子1 皮肤 |
| 文章编号： | 1008-2409（2007）06-1193-02 |
| 收稿时间： | 2007-06-07 |
| 修稿时间： | 2007年6月7日 |
Effect of emollient preparation on skin ICAM-1 expression induced by Nickel Sulfate |
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| TAO Zan-ying,LING Yue-fu,CHENG Pei-hua.Effect of emollient preparation on skin ICAM-1 expression induced by Nickel Sulfate[J].Acta Medicinae Sinica,2007,20(6):1193-1194. |
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| Authors: | TAO Zan-ying LING Yue-fu CHENG Pei-hua |
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| Institution: | The Affiliated Hospital of Guilin Medical College, Guilin 541001, China |
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| Abstract: | Objective:To study the effect of emollient preparation on skin ICAM-1 expression induced by nickel sulfate.Methods:Cultivated skin was divided into 2 groups: emollient group was treated with topical emollient,no-emollient group was treated with 0.9%NaCl.Both groups were stimulated by NiSO4 for 48 hour. The expression of ICAM-1 was evaluated by immunochemical staining(LSAB) and image analysis.Results:The ICAM-1 expressions in emollient group were more lower than those in no-emollient group(P<0.05).Conclusion:Emollient could suppress the skin expression of ICAM-1 induced by NiSO4.Emollient might have a potential value in the prevention of allergic contact dermatitis. |
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| Keywords: | emollient NiSO4 intercellular adhesion molecule-1 skin |
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