Determination of serum cholestatic factor level by ELISA in drug-induced allergic hepatitis |
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Authors: | Kiyohide Kioka Yasuhiro Mizoguchi MD Chie Kodama Yoshihide Sakagami Shuichi Seki Kenzo Kobayashi Sukeo Yamamoto Seiji Morisawa |
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Institution: | 1. Third Department of Internal Medicine, Osaka City University Medical School, 1-5-7 Asahi-machi, Abeno-ku, 545, Osaka, Japan 2. Osaka Socio-Medical Center Hospital, 557, Osaka, Japan 3. First Department of Biochemistry, Osaka City University Medical School, 545, Osaka, Japan
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Abstract: | We have shown that intrahepatic cholestasis often observed in drug-induced allergic hepatitis may be induced by a kind of
lymphokine, the cholestatic factor (CF). In this study, we measured the CF level in the serum of patients with jaundice by
ELISA using anti-CF monoclonal antibody. As a result, CF was detected in the serum of most of the patients at the peak of
jaundice, but it was not detected when the patients were recovering from jaundice. When the changes in the serum CF level
were followed during the clinical course of a patient, it reached its maximum level before that of the serum total bilirubin
level and quickly decreased thereafter. These results also suggest that intrahepatic cholestasis in drug-induced allergic
hepatitis may be induced by CF. |
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Keywords: | Cholestatic factor Drug-induced allergic hepatitis Intrahepatic cholestasis Monoclonal antibody |
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