Patent Evaluation: Halopropargylated cyclic quaternary ammonium compounds as antimicrobial agents

Novelty: Novel halopropargylated cyclic quaternary ammonium compounds are disclosed which are useful as antimicrobial agents and possess activity against a broad spectrum of fungi and bacteria, as well as low toxicity and favourable environmental profiles.

Biology: The compounds were assaycd for their bacterial and fungicidal ability using MIC tests against P. aeruginosa, S. aureus, E. coli and A. niger. Results are given in four tables. The compounds show excellent activity again3 Gram-negative bacteria such as E. coli.

Chemistry: Syntheses of the compounds are described in five examples, including that of 1 -tetradecyl- 1 -(3-iodopropargyl)pyrrolidinium 4-methylbenzenesulphonate.