5-HT1B/1D antagonists and depression |
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Abstract: | The molecular pharmacology, functional role and behavioural implications of central 5-HT1B/1D receptors suggest that these particular receptor subtypes probably play an important role in brain serotonin neurotransmission. This article summarises the rationale for considering 5-HT1B/1D antagonists as potential new, fast-acting antidepressants and describes the development of recent selective potent 5-HT1B/1D antagonists, reviewing both the primary and patent literature. |
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