长春瑞宾治疗48例晚期非小细胞肺癌疗效分析

目的评价长春瑞宾(诺维本，NVB)对晚期非小细胞肺癌(NSCLC)的治疗作用。方法采用诺维本为主药的联合方案治疗非小细胞肺癌48例，均为初治患者，均经细胞学或病理证实。结果本组48例中，没有完全缓解病例，部分缓解20例，有效率为41．7％，其中腺癌有效率为53．5％，鳞癌有效率为25．00％，其差异有显著性。NP方案：诺维本(NVB) 顺铂(PDD)治疗20例，有效率为40．0％；NI方案：NVB IFO(异环磷酰胺)治疗28例，有效率为42．8％，两方案差异无显著性。它不仅能使肿块缩小，缓解症状，而且对骨转移性疼痛及溶骨性破坏疗效更好。对肺鳞癌加上放疗，将获得更好的效果。主要毒性为骨髓抑制及消化道反应。结论NP或NI方案是治疗非小细胞肺癌，尤其是合并骨转移者较为理想的方案。

Short term effect of navetbine on 48 cases of non-smal cell lung cancer

Objective To evaluate effect of navelbine on-small cell lung cancer (NSCLC).Methods Forty eight cases of advanced NSCLC confirmed cytologically and pathologically were treated with combined chemotherapy including mavelbine as the cardinal drug from May, 1996 to January, 1999. They were randomly divided into two groups. One group of 20 cases was treated with NP regimen (NVB+PDD); the other cases were treated with NI regimen (NVB+IFO) All patients received no previous treatment. Results There was no complete response in patients treated with either regimen. Partial response was observed in 8 of 20 NP-treated patients (40.0%) and in 12 of 28 NI-treated patients (42.8%).There was no statistical difference in response rate bettwen these 2 groups of NSCLC patients.However, in both groups of patients ,the therapeutic effect was better on adenocarcinoma than on Sequamous-cell acarcinoma patients.NP regimen seemed effective in the control of bone metastases and paons.Side effects were mainly myelo-suppression and digestive tract reaction.Conclusion Combined chemotherapy includeing NVB is effective for advanced NSCLC especially those with bone metastasis.