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Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice |
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| Authors: | Tetsuya Kouno Suling Zeng Yanhan Wang Yi Duan Sonja Lang Bei Gao Phillipp Hartmann Noemí Cabré Cristina Llorente Chloé Galbert Patrick Emond Harry Sokol Michael James Chun Cheih Chao Jian-Rong Gao Mylene Perreault David L. Hava Bernd Schnabl |
| Affiliation: | 1. Department of Medicine, University of California San Diego, La Jolla, California, USA;2. Department of Medicine, University of California San Diego, La Jolla, California, USA Department of Gastroenterology and Hepatology, Faculty of Medicine, University Hospital Cologne, University of Cologne, Cologne, Germany;3. Department of Medicine, University of California San Diego, La Jolla, California, USA Department of Pediatrics, University of California, San Diego, La Jolla, California, USA Division of Gastroenterology, Hepatology and Nutrition, Rady Children's Hospital San Diego, San Diego, California, USA;4. INSERM UMRS-938, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Sorbonne Université, Paris, France Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France;5. UMR 1253, iBrain, Inserm, University of Tours, Tours, France Medical Biology Center, CHRU Tours, Tours, France;6. INSERM UMRS-938, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Sorbonne Université, Paris, France Paris Center for Microbiome Medicine (PaCeMM) FHU, Paris, France INRAe, AgroParisTech, Micalis Institute, Jouy-en-Josas, France;7. Synlogic Inc., Cambridge, Massachusetts, USA |
| Abstract: | |
| Keywords: | alcohol-related liver disease microbiome microbiota synthetic biology |