Mechanisms of diabetic foot ulceration: A review |
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Authors: | Haibo Deng Binghui Li Qian Shen Chenchen Zhang Liwen Kuang Ran Chen SiYuan Wang ZhiQiang Ma Gongchi Li |
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Affiliation: | 1. Department of Wound Repair, Liyuan Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China;2. School of Foreign Studies, Zhongnan University of Economics and Law, Wuhan, Hubei, China;3. Department of Hand Surgery, Union Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China |
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Abstract: | Diabetic foot ulcers (DFUs) are associated with complex pathogenic factors and are considered a serious complication of diabetes. The potential mechanisms underlying DFUs have been increasingly investigated. Previous studies have focused on the three aspects of diabetic peripheral vascular disease, neuropathy, and wound infections. With advances in technology, researchers have been gradually conducting studies using immune cells, endothelial cells, keratinocytes, and fibroblasts, as they are involved in wound healing. It has been reported that the upregulation or downregulation of molecular signaling pathways is essential for the healing of DFUs. With a recent increase in the awareness of epigenetics, its regulatory role in wound healing has become a much sought-after trend in the treatment of DFUs. This review focuses on four aspects involved in the pathogenesis of DFUs: physiological and pathological mechanisms, cellular mechanisms, molecular signaling pathway mechanisms, and epigenetics. Given the challenge in the treatment of DFUs, we are hopeful that our review will provide new ideas for peers. |
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Keywords: | diabetic foot ulcer wound healing epigenetics physiology and pathology signaling pathway 糖尿病足溃疡 创面愈合 表观遗传学 生理病理 信号通路 |
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