首页 | 本学科首页   官方微博 | 高级检索  
     


Current and future approaches to screening for endometrial cancer
Affiliation:1. Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA;2. Pathology and Medical Oncology Departments, Hospital Universitari Arnau de Vilanova, IRBLLEIDA, CIBERONC, University of Lleida, Lleida, Spain;3. Gynecologic Medical Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA;4. Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA;5. Radiology Department, Institut de Diagnòstic per la Imatge / Hospital Universitari Arnau de Vilanova, IRBLLEIDA, University of Lleida, Lleida, Spain;6. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA;7. Pathology Department, Hospital Universitaride Bellvitge, IDIBELL, University of Barcelona, Barcelona, Spain;1. Department of Pathology, The Mater Hospital, Brisbane, Queensland, Australia;2. Department of Histopathology, King Edward Memorial Hospital, Perth, WA, Australia;3. School for Woman''s and Infants'' Health, University of Western Australia, Perth, WA, Australia;4. Population Health Department QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia;5. School of Medicine, The University of Queensland, QLD, Australia;6. Queensland Centre for Gynaecological Cancer, Brisbane, QLD, Australia;7. Queensland Centre for Gynaecological Oncology, University of Queensland, School of Medicine, Central Clinical Division, Brisbane, Australia;8. The University of Queensland, School of Public Health, Brisbane, Australia
Abstract:Due largely to the rise in obesity and prolonged life expectancy, endometrial cancer (EC) rates have increased by 56% since the early 90s. Women at high risk (Lynch Syndrome) have a 12–47% lifetime risk of developing EC and professional societies recommend annual surveillance using transvaginal ultrasound (TVS) and endometrial biopsy (outpatients hysteroscopy) from the age of 30–35 years with hysterectomy from the age of 40 years. In women at low risk, screening is not currently advocated. The emerging data from Genome Wide Association studies (GWAS) in combination with epidemiological data may refine risk stratification in the future. In addition to screening, preventative approaches such as intrauterine progesterone may help reduce disease burden in those identified at ‘higher risk’.
Keywords:Endometrial cancer  Risk factors  Screening  Transvaginal ultrasound  Endometrial sampling  Lynch syndrome
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号