非小细胞肺癌伴神经内分泌分化的研究

目的：研究非小细胞肺癌的类型、分化程度与神经内分渥分化间接的关系。方法：随机收集４３例手术切除石蜡包埋的非小细胞肺癌的标本，采用７种神经内分泌抗体，用免疫组化ＬＳＡＢ法研究其神经内分泌分化。结果：阳性率为５３．４％，其中鳞癌和腺癌的阳性率分别为：５２．９％和５８．３％；而２例大细胞癌皆阴性。结论：非小细胞肺癌的组织类型与神经内分泌表达的种类有一定关系；而组织学类型和癌细胞分化程度与神经内分泌分化的

Study on neuroendocrine differentiation in non small cell carcinoma of the lung

Purpose:To study the correlation of the histological type and differentiation degree between neuroendocrine differentiation in non small cell carcinoma of the lung. Methods The neuroendocrine differentiation was studied in 43 surgically resected and paraffin embedded non small cell carcinoma specimens of lung by immunohistochemistry(LSAB method) using seven antibodies against neuroendocrine antigen. Results It was found that 23 cases (53 4%) was the positive reactivity, including 9 squamous (52 9%) and 14 adenocarcinomas(58 3%). However, two large cell carcinomas were negative. Conclusions The positive reactivities to various neuroendocrine antibodies are correlated with the histological type, but neuroendocine differentiation is not correlated with histological type and degree of histological differentiation.