Effects of oestrogenic agents on rat peritoneal mast cells |
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Authors: | S. Lai E. K. Fishman H. Lai H. Pannu B. Detrick |
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Affiliation: | (1) Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA;(2) Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, USA;(3) Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA |
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Abstract: | Objectives and design: The objective of this study was to explore whether increased levels of inflammatory cytokines are associated with the risk of clinically silent coronary artery disease. Subjects: Three-hundred-fifty-six black adults aged 25–54 residing in inner city of Baltimore, Maryland, United States were included in this study. Methods: Sociodemographics were assessed as were lipid profiles, IL-6, tumor necrosis factor-alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (sICAM-1), and high-sensitivity C-reactive protein (hs-CRP) levels. Computed tomography (CT) coronary angiography was performed. Results: Coronary calcification was identified in 22.5 % participants and 14 % had significant (≥50 %) coronary stenosis. Multiple logistic regression analyses suggested that IL-6 levels were independently associated with the presence of coronary calcification and significant coronary stenosis, while TNF-alpha, sICAM-1 and hs-CRP levels were not. Conclusions: This study underscores a critical role for IL-6 in atherosclerosis and suggests that IL-6 may be a marker for significant coronary stenosis in cardiovascularly asymptomatic individuals. This research was funded by National Institute on Drug Abuse grants RO1-DA12777 (Lai S), and RO1-DA15020 (Lai S). Received 22 November 2007; returned for revision 28 May 2008; received from final revision 6 August 2008; accepted by M. Parnham 7 August 2008 |
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Keywords: | KeywordHeading" >: Interleukin-6 (IL-6) Significant coronary stenosis CT coronary angiography Marker for clinically silent CAD Black race |
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