急性冠状动脉综合征患者血清IL-10及IL-12水平测定

目的 :探讨白细胞介素 - 10 (IL- 10 )、白细胞介素 - 12 (IL- 12 )对动脉粥样硬化 (AS)形成和发展的影响。方法 :分别对 18例急性心肌梗死 (AMI)患者于发病当天及第 3,5 ,7,10 ,14天 ;14例不稳定型心绞痛 (UAP)患者及 10例健康对照者测定血清 IL - 10、IL - 12水平。结果 :1U AP患者 IL - 10、IL - 12水平显著高于对照组。 2A MI患者血清 IL - 10于发病当天至第 5天显著高于其他两组 ,并于第 3天达高峰。 IL - 12于发作当天及第 10～ 14天显著高于对照组。3AMI死亡组 IL - 10水平明显高于生存组 ,而 IL - 12无显著性差异。结论 :提示急性冠状动脉事件患者 IL - 10、IL - 12升高 ,二者可能参与了 A S的形成和发展 ,并可作为急性期预测指标。

The determination and significance of IL-10/IL-12 in sera of patients with acute coronary artery syndrome

Objective:To determine the levels of IL 10 and IL 12 in sera from patients with acute coronary artery syndrome (ACS), and to investigate the relationship between these levels and the degree of AS. Method:IL 10 and IL 12 levels in sera were assayed by ELISA from 18 patients with acute myocardial infarction (AMI) and from 14 patients with unstable angina pectoris(UAP) and 10 normal controls. Result:The levels of IL 10 and IL 12 in sera from the UAP group were much higher than those of controls. IL 10 levels in sera from the AMI group on the first to fifth days after onset were higher than those of the other two groups, and the IL 10 level on the seventh days after onset was higher than those of controls, and reached its maximum on the third days after onset. However, the level of IL 12 in sera was significantly higher than that of controls on the onset day and the tenth to fourteenth days. Among AMI patients, only the peak IL 12 level on the fourteenth day was significantly higher than that of UAP patients. On the third day after onset, IL 10 level in sera of dead patients with AMI was higher than that of survivors. Conclusion:Compared to normal controls, patients with acute coronary artery syndrome have higher levels of IL 10 and IL 12, which indicate the potential roles played by IL 10/IL 12 in the process of AS. The cross regulatory roles of IL 10 and IL 12 may contribute to the pathogenesis of AS, specifically, these factors may act as indicators of AS severity and prognosis of AMI.