| 粉防己碱对有机磷酸酯抑制的胆碱酯酶活性的影响 |
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| 引用本文： | 熊玉卿,傅军,刘汉清,李艳艳. 粉防己碱对有机磷酸酯抑制的胆碱酯酶活性的影响[J]. 中草药, 2002, 33(3): 236-238 |
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| 作者姓名： | 熊玉卿 傅军 刘汉清 李艳艳 |
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| 作者单位： | 江西医学院临床药理研究所,江西,南昌,330006 |
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| 基金项目： | 国家自然科学基金资助项目(No.39760082) |
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| 摘 要： | 目的研究粉防己碱(Tet)对有机磷酸酯抑制的胆碱酯酶(ChE)活性的影响.方法采用Ellman's比色法测定人血ChE活性作为观察指标.结果Tet使敌百虫抑制的ChE活性量效曲线右移,最大抑制反应明显压低;0.4,0.8,1.6μ/mL Tet的最大复活效应分别为20.5%、38.3%和80.2%(P＜0.05);Tet与氯磷定(PAM-Cl)活化被抑制酶的ECs0分别为0.69和2.01 μg/mL.结论提示Tet是被抑制的ChE复活剂.
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| 关 键 词： | 粉防己碱 敌百虫 胆碱酯酶 重活化剂 |
| 文章编号： | 0253-2670(2002)03-0236-03 |
| 收稿时间： | 2001-06-11 |
| 修稿时间： | 2001-06-11 |
Influence of tetrandrine on activity of cholinesterase in hibited by organophosphate |
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| Xiong Yuqing,Fu Jun,Liu Hanqing and Li Yanyan. Influence of tetrandrine on activity of cholinesterase in hibited by organophosphate[J]. Chinese Traditional and Herbal Drugs, 2002, 33(3): 236-238 |
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| Authors: | Xiong Yuqing Fu Jun Liu Hanqing Li Yanyan |
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| Affiliation: | Institute of Clinical Pharmacology, Jiangxi Medical College, Nanchang Jiangxi 330006, China;Institute of Clinical Pharmacology, Jiangxi Medical College, Nanchang Jiangxi 330006, China;Institute of Clinical Pharmacology, Jiangxi Medical College, Nanchang Jiangxi 330006, China;Institute of Clinical Pharmacology, Jiangxi Medical College, Nanchang Jiangxi 330006, China |
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| Abstract: | |
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| Keywords: | tetrandrine(Tet) dipterex cholinesterase reactivator |
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