黄芪桂枝五物汤对大鼠的长期毒性研究

目的 观察黄芪桂枝五物汤（浸膏）长期用药对大鼠所产生的毒性反应。方法 连续给药13周，试验期间对大鼠的外观、行为、体质量以及摄食等各项指标进行观察检测，并分别于给药结束和恢复期结束进行血液学、血液生化学以及病理组织学检查。结果 在黄芪桂枝五物汤（浸膏）给药期间、给药结束后以及恢复期，大鼠体质量、摄食、血液学、血液生化学和病理组织学等均未见毒理学意义的异常改变。结论 在本实验条件下，黄芪桂枝五物汤（浸膏）24.0 g/(kg·d)（相当于临床拟用日剂量109倍）为无毒反应剂量，表明该药物具有相当大的安全范围。

Long term toxicity of Huangqi Guizhi Wuwu Decoction on rats

Objective To observe the toxic reaction of Huangqi Guizhi Wuwu Decoction on rats by long-term drug toxicity. Methods During the experiment, certain index of appearance, behavior, weight, and food intake were detected after successive administration for 13 weeks, and then, the hematology, blood-biochemics, and pathohistology in end administration period and recovery period were examined, respectively. Results Huangqi Guizhi Wuwu Decoction has no toxicological abnormal changes of weight, food intake, hematology, blood-biochemics, and pathohistology during administration end administration, and convalescent periods. Conclusion In the situation of this experiment, 24.0 g/(kg·d) (109 times dosage as much as that of clinical daily dose) of Huangqi Guizhi Wuwu Decoction is the non-toxic reaction dosage, which indicates that the drug has a sizable margin of safety.