| 昆明山海棠水抽提物诱发小鼠骨髓细胞非整倍体的研究 |
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| 引用本文： | 汪旭 合正基. 昆明山海棠水抽提物诱发小鼠骨髓细胞非整倍体的研究[J]. 癌变．畸变．突变, 1992, 4(6): 11-14,F004 |
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| 作者姓名： | 汪旭 合正基 |
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| 作者单位： | 云南师范大学生物系，云南师范大学生物系，云南师范大学生物系，云南师范大学生物系，云南师范大学生物系 昆明 650092，昆明 650092，昆明 650092，昆明 650092，昆明 650092 |
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| 摘 要： | 以C—有丝分裂效应、微核及染色体结构畸变分析,综合评估了中药昆明山海棠根部水抽提物(THH)在小鼠骨髓细胞中的非整倍体诱发能力。结果表明,THH具有类似于秋水仙素的非整倍体诱发效应:(1)导致骨髓细胞有丝分裂指数、C—有丝分裂细胞频率显著升高,有丝分裂后期频率显著下降;(2)于小鼠骨髓嗜多染红细胞中诱发微核却无染色体断裂效应。提示THH为一种哺乳动物体细胞非整倍体诱发剂。
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| 关 键 词： | 昆明山海棠 染色体畸变 非整倍性 |
A STUDY OF ANEUPLOID INDUCTION BY THE WATER EXTRACT OF TRIPTERYGIUM HYPOGLAUCUM (LEVL) HUTCH IN MOUSE BONE MARROW CELLS |
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| Abstract: | The water extract of a Chinese herb, Triptergium hypoglaucum (Levl) Hutch(THH)has been assayed by means of C-mitotic effects(CM), micronucleus (MN)and chromosomal structural aberration (CA)tests for its effects of aneuploid induction in mouse bone marrow cells.THH showed positive responses both in CM and MN tests but nonclastogenic in CA analysis. Ths results indicated that THH may share some aneuploidy-inducing potential similar to that of colchicine. |
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| Keywords: | Tripterygium hypoglaucum(Levl)Hutch aneugen C-mitotic effect micronucleus chromosomal structural aberration |
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