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| 三氧化二砷对小鼠肝癌生物学行为的影响 | |
| 引用本文： | 黄朔,沈延兴,梁桃,李明振,金琦.三氧化二砷对小鼠肝癌生物学行为的影响[J].中国基层医药,2010,17(1):9-11. |
| 作者姓名： | 黄朔 沈延兴 梁桃 李明振 金琦 |
| 作者单位： | 1. 佳木斯大学第一附属医院普外科,黑龙江省佳木斯,154002 2. 黑龙江省鹤岗市红十字医院内科 3. 哈尔滨医科大学第一临床医学院内科 4. 佳木斯大学第一附属医院内科,黑龙江省佳木斯,154002 |
| 基金项目： | 黑龙江省卫生厅资助项目，黑龙江省教育厅资助项目 |
| 摘 要： | 目的研究三氧化二砷对HepA小鼠肝癌生长、血管生成及侵袭与转移特性的影响。方法建立皮下种植肝癌小鼠模型，用药后观察小鼠肿瘤体积变化及抑瘤率；利用免疫组织化学观察移植瘤中血管内皮生长因子（VEGF），对移植瘤的微血管密度（MVD）进行计数。结果三氧化二砷对小鼠肝癌瘤体体积和抑瘤率均具有抑制作用；三氧化二砷能抑制肿瘤新生血管生成，降低VEGF的表达，并能降低肿瘤MVD，与未用药对照组相比差异均有统计学意义（P〈0．05）。结论三氧化二砷能缩小肿瘤体积、增加抑瘤率，并能降低VEGF的表达，减少微血管密度。 |
| 关 键 词： | 三氧化二砷 肝肿瘤，实验性 小鼠 |
Effect of As_2O_3 on hepatocacinoma |
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| HUANG Shuo,SHEN Yan-xing,LIANG Tao,LI Ming-zhen,JIN Qi.Effect of As_2O_3 on hepatocacinoma[J].Chinese Journal of Primary Medicine and Pharmacy,2010,17(1):9-11. | |
| Authors: | HUANG Shuo SHEN Yan-xing LIANG Tao LI Ming-zhen JIN Qi |
| Institution: | . ( Department of General Surgery, The First Hospital Affiliated to Jiamusi University,Jiamusi ,Heilongfiang 154002, China ) |
| Abstract: | Objective To study the effects of As_2O_3 on tumor model of hepatocarcinoma.Methods HepAgrafed hepatocarcinoma mouse model was established by subcutaneously injection of mouse hepatoma cells(1×10~6)into the oxter of mice.After treated by As_2O_3,the volume change of tumor and tumor inhibition rates were observed.The expression of vascular endothelial growth factor(VEGF) was detected by immunohistochemical and calculated the difference of MVD.Results The volume of tumor and the tumor inhibition rates were significantly decreased in As_2O_3 group compared with control group(P<0.05).The As_2O_3 could inhibit angiogenesis of xenograft tumor,depress expression of VEGF and decrease microvascular density(MVD).Conclusion As_2O_3 can inhibit the growth of tumor,inhibit the expression of VEGF and decrease MVD. |
| Keywords: | Arsenic trioxide Liver neoplasms experimental Mice |
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