脑梗死患者急性期血浆PAI-1与t-PA比值的变化及临床意义 |
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引用本文: | 汪效松,雷惠新,张旭,程琼,周秀珍. 脑梗死患者急性期血浆PAI-1与t-PA比值的变化及临床意义[J]. 中医药研究, 2010, 0(8): 942-943 |
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作者姓名: | 汪效松 雷惠新 张旭 程琼 周秀珍 |
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作者单位: | 福建省立医院,350001 |
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基金项目: | 福建省科技基金资助项目(No.2001Z158) |
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摘 要: | 目的研究脑梗死患者急性期(发病7 d内)血浆纤溶酶原激活物抑制物-1(PAI-1)与血浆组织型纤溶酶原激活物(t-PA)比值的变化及其临床意义。方法采用酶联免疫吸附法检测67例脑梗死患者急性期血浆PAI-1t、-PA、计算PAI-1/t-PA(P/t)值,并与50名健康对照组作对照。结果脑梗死患者急性期血浆t-pA活性及PAI-1活性均升高,与正常对照组比较有统计学意义(P〈0.05),P/t值较正常对照组降低(P〈0.05)。结论脑梗死患者急性期体内纤溶活性相对亢进。在判定体内纤溶活性指标中,P/t值较t-PA、PAI-1稳定可靠。P/t值与纤溶活性呈反比关系。
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关 键 词: | 脑梗死 组织型纤溶酶原激活物 纤溶酶原激活物抑制物-1 血浆 |
The Level of Plasma PAI-1/t-PA in Acute Cerebral Infarction and Its Clinical Significance |
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Affiliation: | Wang Xiaosong,Lei Huixin,Zhang Xu,et al Department of Neurology,Fu Jian Provincial Hospital(Fuzhou 350001) |
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Abstract: | Objective To study the levels of plasma t-PA,PAI-1 and PAI-1/t-PA(P/t)in patients with acute cerebral infarction,and to investigate its clinical significance.Methods Sixty-seven patients with acute cerebral infarction were selected as observation group.Fifty healthy persons were as control group.The levels of plasma t-PA and PAI-1 were tested with ELISA.Results Compared with control group,the levels of t-PA and PAI-1 were increased in observation group(P0.05).The value of P/t in observation group was lower than that in control group(P0.05).Conclusion The relative increase of fibrinolytic activity was the feature of the patients with acute cerebral infarction.The P/t might represent the fibrinolytic activity.The P/t was inverse proportion to the fibrinolytic activity. |
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Keywords: | cerebral infarction tissue-type plasminogen activator plasminogen activator inhibitor-1 plasma |
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