脑梗死患者急性期血浆PAI-1与t-PA比值的变化及临床意义

目的研究脑梗死患者急性期（发病7 d内）血浆纤溶酶原激活物抑制物-1（PAI-1）与血浆组织型纤溶酶原激活物（t-PA）比值的变化及其临床意义。方法采用酶联免疫吸附法检测67例脑梗死患者急性期血浆PAI-1t、-PA、计算PAI-1/t-PA（P/t）值,并与50名健康对照组作对照。结果脑梗死患者急性期血浆t-pA活性及PAI-1活性均升高,与正常对照组比较有统计学意义（P〈0.05）,P/t值较正常对照组降低（P〈0.05）。结论脑梗死患者急性期体内纤溶活性相对亢进。在判定体内纤溶活性指标中,P/t值较t-PA、PAI-1稳定可靠。P/t值与纤溶活性呈反比关系。

The Level of Plasma PAI-1/t-PA in Acute Cerebral Infarction and Its Clinical Significance

Objective To study the levels of plasma t-PA,PAI-1 and PAI-1/t-PA（P/t）in patients with acute cerebral infarction,and to investigate its clinical significance.Methods Sixty-seven patients with acute cerebral infarction were selected as observation group.Fifty healthy persons were as control group.The levels of plasma t-PA and PAI-1 were tested with ELISA.Results Compared with control group,the levels of t-PA and PAI-1 were increased in observation group（P0.05）.The value of P/t in observation group was lower than that in control group（P0.05）.Conclusion The relative increase of fibrinolytic activity was the feature of the patients with acute cerebral infarction.The P/t might represent the fibrinolytic activity.The P/t was inverse proportion to the fibrinolytic activity.