丹红注射液联合贝那普利治疗老年高血压合并早期肾损害的临床观察

目的观察丹红注射液联合贝那普利治疗老年高血压合并早期肾损害的临床疗效。方法老年高血压合并尿微量白蛋白（MAU）阳性者204例，随机分为丹红注射液联合贝那普利组（观察组）与贝那普利组（对照组）。观察组给予丹红注射液静脉输注并口服贝那普利，对照纽单纯给予贝那普利口服。观察治疗4周后MAU、血β2微球蛋白（β2-MG）、尿β2-MG、尿N乙酰-B—D氨基葡萄糖苷酶（NAGE）、血管紧张素Ⅱ（AngⅡ）变化情况。结果治疗后观察组MAU、血β2—MG、尿β2-MG、尿NAGE、AngⅡ对照组减少更为明显，分别为（95．02±38．98）mg／dVS（126．95±34．31）mg／d，（2．99±1．30）mg／dvs（3．34±0．98）mg／d，（151．38±1．27）mg／dvs（190．19±2．6）mg／d，（20．47±4．17）U／LVS（22．15±3．79）U／L，（54．41±24．11）ng／Lvs（55．78±6．90）ng／L，两组比较均有统计学意义（P〈0．05）；肾功能（肌酐）变化两组间差异无统计学意义。结论丹红注射液联合贝那普利治疗老年高血压合并早期肾损害的临床疗效优于单纯使用贝那昔利。

Clinical Observation on Danhong Injection with Benazepril for Elderly Hypertensive Patients with Early Kidney Demage

Objective To observe the therapeutic effect of Danhong injection with benazepril on elderly patients （pts） with essen tial hypertension and early kidney damage. Methods Two hundreds and four elderly pts with essential hypertension and positive uri- nary albumin （MAU） were randomly divided into two groups： Treatment group treated with Danhong injection and benazepril and control group treated with benazepril for four weeks. The levels of MAU, blood and urinary β2 microglobulin （β2 - MG）, urinary NAG enzyme （NAGE） ,blood angioension Ⅱ （Ang Ⅱ ）, kidney function were measured after four weeks treatment. Results The levels of MAU,blood and urinary β2 - MG,NAGE and Ang Ⅱ in treatment group were lower obviously than that in control group. That were （95.02-4±38.98）mg/dvs（126.95±34.31）mg/d,（2.99±1.3%）mg/dvs（3.34±0.98）mg/d,（151.38± 27）mg/dvs（190. 19± 2.6） mg/d,（20.47±4.7） U/L vs（22.15±3. 79） U/L,and （54.41±24.1） ng/L vs（55. 78±6. 90） ng/L. Creatine had no obvious changes in two groups. Conclusion Therapeutic effect of Danhong injection with benazepril was better than that of benazepril on elderly pts with hypertension and early kidney damage.