丹参多酚酸盐对老年不稳定型心绞痛患者血清细胞因子水平的影响 |
| |
引用本文: | 吴兴利,裴翔,李德印,李金珉,杨丁友,高玉玲,朱梅,陈琪,王士雯.丹参多酚酸盐对老年不稳定型心绞痛患者血清细胞因子水平的影响[J].中医药研究,2010(2):158-160. |
| |
作者姓名: | 吴兴利 裴翔 李德印 李金珉 杨丁友 高玉玲 朱梅 陈琪 王士雯 |
| |
作者单位: | 中国人民解放军总医院老年心血管疾病研究所,100853 |
| |
基金项目: | 中国人民解放军总后勤部十一五重点课题基金项目(No.2007-hz-014) |
| |
摘 要: | 目的研究丹参多酚酸盐治疗对老年不稳定型心绞痛(UAP)患者血清细胞因子水平的影响。方法将72例UAP患者随机分为常规治疗组及丹参多酚酸盐治疗组(丹参多酚酸盐组),观察治疗前后血清白细胞介素18(IL-18)、白细胞介素1(IL-1)以及可溶性细胞间黏附分子-1(sICAM-1)水平的变化,并与18名正常对照组作比较。结果uAP患者血清IL-18、IL-1、sICAM-1水平较正常对照组明显升高(P〈0.01),常规治疗组治疗后血清IL-18、IL-1较治疗前降低(P〈0.05或P〈0.01),而在丹参多酚酸盐组IL-18、IL-1、sICAM-1均较治疗前明显降低(P〈0.01),且丹参多酚酸盐组治疗后较常规治疗组下降明显(P〈0.05或P〈0.01)。结论IL-18、IL-1和sICAM-1可能不同程度参与老年不稳定型心绞痛的病理生理进程。丹参多酚酸盐对UAP患者的心血管保护作用与其显著降低IL-18、1L-1以及sICAM-1水平,从而抑制冠脉局部的炎症级联反应有关。
|
关 键 词: | 老年人 不稳定型心绞痛 丹参多酚酸盐 细胞因子 |
Effect of Salvianolate on Serum Cytokins Level in Elderly Patients with Unstable Angina Pectoris |
| |
Affiliation: | Wu Xingli,Pei Xiang,Li Deyin,et al (Institute of Geriatric Cardiology,The General Hospital of the People's Liberation Army Beijing 100853) |
| |
Abstract: | Objective To investigate the effect of salvianolate on the serum cytokins level in elderly patients (pts) with unstable angina pectoris (UAP). Methods Seventy- two pts were divided randomly into conventional therapy group and salvianolate group. The levels of interleukin - 18 (IL - 18),interleukin - 1 (IL - 1 ) and intercellular adhesion molecular (ICAM - 1 ) were evaluated by ELISA method before and 2 weeks after therapy. The levels of the cytokins were compared with 18 normal controls. Results The levels of serum IL- 18, IL- 1 and sICAM - 1 in patients with UAP were higher than that in the control group(P〈0.01) and the levels of IL - 18 and IL - 1 were decreased after treatment with conventional therapy(P〈0. 05 or P〈0. 01). The levels of serum IL- 18 ,IL- 1 and sICAM- 1 were decreased after treatment with salvianolate therapy(P〈0.01), with more significant effect compared with conventional therapy group(P〈0.05 or P〈0.01). Conclusion The result suggested that IL - 18, IL - 1 and sICAM - 1 might be involved in the development of unstable angina pectoris. Salvianolate might inhibit the inflammatory injury in coronary artery by decreasing the secretion of IL- 18 ,IL- 1 and sICAM - 1 in the eider pts with UAP. |
| |
Keywords: | elderly unstable angina pectoris salvianolae cytokins |
本文献已被 维普 等数据库收录! |