Snail E-cadherin与宫颈病变的相关性研究

目的:探索在宫颈癌变过程中E-cadherin、Snail的变化规律及二者之间的关系和临床意义。方法:选取宫颈组织标本共115例,用免疫组化SP法检测宫颈不同组织学阶段标本中E-cadherin、Snail蛋白的表达情况,分析其与临床肿瘤发生、发展的关系。结果:随着由慢性宫颈炎向宫颈上皮内瘤样病变乃至宫颈癌的逐步发展,E-cadherin蛋白的阳性表达逐渐减弱,Snail蛋白的阳性表达逐渐增强,各种组织间均存在差异,有统计学意义(P<0.05);E-cadherin蛋白表达Snail的蛋白表达呈负相关(P<0.01)。结论:Snail在慢性宫颈炎组织,宫颈上皮内瘤样病变(CIN),宫颈癌3个组织学阶段表达逐渐增强,E-cadherin在这3个阶段表达递减,其改变使癌细胞易于从癌组织上脱落,进而浸润、转移,Snail调节E-cadherin的表达。

Correlationship between Snail and E-cadherin and Cervical Lesions

Objective:To investigate the changes of E-cadherin and Snail in cervical cancers and their relationships and the clinical significance.Methods:The expression of E-cadherin and Snail in 115 cases of cervical tissues was detected by SP methods.Their relationship with genesis and development of tumors was analyzed.Results:With the development of chronic cervicitis to cervical intraepithelial tumor-like lesion(CIN)to cervical cancer,the positive expression of E-cadherin was decreased and the positive expression of Snail was increased,the difference between various tissues was significant(P<0.05).The expression of E-cadherin was negatively related to that of Snail(P<0.01).Conclusion:In tissues of chronic cervicitis and CIN and cervical cancer,the expression of E-cadherin is gradually decreased and the expression of Snail is gradually in creased,which induced tumor cells easy to fall off,then infiltrate and metastasize,Snail regulates the expression of E-cadherin.