小儿花剥苔形成的相关因素及其免疫学机制

目的：探讨小儿花剥苔发生的主要相关因素及其免疫学机制.方法：运用临床流行病学方法调查1562例儿童,同时采用流式细胞术检测T、B淋巴细胞亚群、细胞趋化因子受体 3（CCR3）、细胞趋化因子受体 5（CCR5）表达量等.结果：花剥苔形成的主要因素为过敏、哮喘史、感染、先天体质等.花剥苔组T、B淋巴细胞亚群及CCR3、白细胞介素4水平高于非花剥苔组及正常组（P〈0.05）.结论：小儿花剥苔形成与过敏、感染、哮喘史、先天体质密切相关,且T、B淋巴细胞亚群改变为花剥苔形成的免疫学机制提供了客观依据.

Correlative Factors of Child Lingua Geographica Formation and the Immunological Mechanism

Objective:To approach to main correlative factors of child lingua geographica formation and the immunological mechanism.Methods:1562 children were surveyed with clinical epidemiological method,and flow cytometry was used to determin T- and B-lymphocyte subgroups and expression of cell chemotactic factor receptor-3(CCR3) and cell chemotoctic factor receptor-5(CCR5).Results:The main correlative factors of child lingua geographica formation were anaphylaxis,asthma history,infection,congenital constitution.The levels of T- and B-lymphocyte subgroups,CCR3 and interlukin-4 in the lingua geographica group were higher than that in the non-lingua geographica group and the control group(P<0.05).Conclusion:Formation of child lingua geographica is closely related with anaphylaxis,asthma history,infection and congenital constitution,and the changes of T- and B-lymphocyte subgroups provide an objective basis for immunological mechanisms of child lingua geographica formation.