子宫颈腺癌中ILK与E-Cadherin蛋白表达的关系

目的探讨子宫颈腺癌组织中整合素连接激酶（ILK）与E-Cadherin的表达关系。方法采用免疫组织化学方法检测106例子宫颈腺癌组织中和22例慢性子宫颈炎组织中ILK与E-Cadherin的表达。结果106例子宫颈腺癌组织ILK的阳性表达率为86.8%,高于慢性子宫颈炎组织（P〈0.01） E-Cadherin蛋白表达率为58.5%,低于慢性子宫颈炎组织81.8%（P〈0.05）。ILK在子宫颈腺癌病理分级,G3组阳性表达率均明显高于G1组（P〈0.05）。E-Cadherin表达与子宫颈腺癌组织类型有关,透明细胞腺癌阳性表达率低于子宫颈内膜腺癌和子宫内膜样腺癌（P〈0.05）。ILK阳性表达强度与E-Cadherin的阳性表达强度呈负相关（P〈0.05）。结论ILK与E-Cadherin在子宫颈腺癌组织中的表达密切相关,E-Cadherin低表达与ILK增强表达在子宫颈腺癌的发生发展中起重要作用,三者可能作为子宫颈腺癌恶性化的分子标志。

Relationship of ILK Expression with E-Cadherin in Cervical Adenocarcinoma

Objective To study the relationship of the expression of ILK with E-Cadherin in cervical adenocarcinoma.Methods The expression of ILK with E-Cadherin was determined by immunohistochemistry in 106 cases of cervical adenocarcinoma and 22 cases of cervical chronic inflammation.Results The positive rates of ILK in cervical adenocarcinoma were 86.8%,which were higher than that in cervical chronic inflammation（P0.01）.The positive rates of E-Cadherin in cervical adenocarcinoma was 58.5%,which was lower than that in cervical chronic inflammation（P0.05）.The positive of ILK was significantly higher in G3 than i G1 adenocarcinoma（P0.05）.The expression of E-Cadherin was related to the histologic types,the level of E-Cadherin was lower in clear-cell adenocarcinoma than others（P0.05）.There was negative correlation between the expression of ILK and ECadherin（P0.05）.Conclusion Low-expression of E-Cadherin and over-expression of ILK are closely related in cervical adenocarcinoma and they play an important role in the development of cervical adenocarcinoma.The two biomarkers might be the indicators for the transformation of cervical lesions from benign to malignant status.