CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection |
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| Authors: | Chau-Ting Yeh Chia-Jung Kuo Ming-Wei Lai Tse-Ching Chen Chun-Yen Lin Ta-Sen Yeh Wei-Chen Lee |
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| Affiliation: | (1) Liver Research Unit, Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China;(2) Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan, Republic of China;(3) Department of Pediatric Gastroenterology, Chang Gung Children Hospital, Taoyuan, Taiwan, Republic of China;(4) Department of Pathology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China;(5) Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China |
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| Abstract: | Background CD133 was detected in several types of cancers including hepatocellular carcinoma (HCC), which raised the possibility of stem cell origin in a subset of cancers. However, reappearance of embryonic markers in de-differentiated malignant cells was commonly observed. It remained to be elucidated whether CD133-positive HCCs were indeed of stem cell origin or they were just a group of poorly differentiated cells acquiring an embryonic marker. The aim of this study was to investigate the significance of CD133 expression in HCC in an area endemic for hepatitis B virus (HBV) infection to gain insights on this issue. |
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