| PROGNOSTIC FACTORS IN CERVICAL CARCINOMA |
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| 引用本文： | LU,Ping,路平,LIANG,Qiu-dong,梁秋冬,WEI,Lei,魏磊,ZHENG,Quan-qing,郑全庆. PROGNOSTIC FACTORS IN CERVICAL CARCINOMA[J]. 中国癌症研究, 2002, 14(3): 211-215. DOI: 10.1007/s11670-002-0047-y |
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| 作者姓名： | LU Ping 路平 LIANG Qiu-dong 梁秋冬 WEI Lei 魏磊 ZHENG Quan-qing 郑全庆 |
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| 作者单位： | Department of Maternal and Child Health，Xi抋n Jiaotong University，Xi抋n 710061 2Department of Oncology，The First Hospital，Xinxiang Medical University，Xinxiang 453100 |
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| 摘 要： | Carcinoma of the uterine cervix is the leadinggynecologic malignancy in developing country and is the third leading cause of cancer related death amongfemales. It is very important to explore prognosis factors of cervical carcinoma, however, there are many factors influencing prognosis and it would lead to great deviation to study prognosis only from clinic-pathologic parameters or single factor. Recent studies have focused on celldynamics and sporadic data showed that prognosis of cervical ca…
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| 收稿时间： | 2002-02-28 |
| 修稿时间： | 2002-07-09 |
Prognostic factors in cervical carcinoma |
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| Ping Lu,Qiu-dong Liang,Lei Wei,Quan-qing Zheng. Prognostic factors in cervical carcinoma[J]. Chinese Journal of Cancer Research, 2002, 14(3): 211-215. DOI: 10.1007/s11670-002-0047-y |
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| Authors: | Ping Lu Qiu-dong Liang Lei Wei Quan-qing Zheng |
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| Affiliation: | (1) Department of Maternal and Child Health, Xi’an Jiaotong University, 710061 Xi’an;(2) Department of Oncology, The First Hospital, Xinxiang Medical University, 453100 Xinxiang |
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| Abstract: | Objective: To evaluate factors for prognosis of cervical carcinoma. Methods: Expressions of mn23- HI, erbB3 and erbB4 were examined by immunohistochemical staining. The apoptosis was detected in situ by the TdT mediated duip-biotin nick end-labeling (TUNEL) technique. Mitotic cell were counted by HE dyeing. Results: FIGO stage and lymph node metastasis were the most important factors for evaluating prognosis in adenocarcinoma or squamous cell carcinoma. AI/MI was positively correlated with 5-year survival of cervical carcinoma. Positive expression of nm23-H1 combed with negative expression of erbB4 [nm23-H1(+)/erbB4(-)] predicted good prognosis for adeno-carcinoma. In multivariable Cox regression analysis, only FIGO stage and AI/MI were into equation. Conclusion: FIGO stage and AI/MI were independent evaluating parameter for adenocarcinoma or squamous cell carcinoma. |
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| Keywords: | Cervical carcinoma Prognosis nm23-H1 erbB3 erbB4 Cell apoptosis Proliferation |
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