| EXPRESSION OF P120ctn IN NON-SMALL-CELL LUNG CANCER: A CLINICOPATHOLOGICAL STUDY |
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| 引用本文： | ZHANG,Zhi-kun张志坤,LIN,Dong林东,WANG,En-hua王恩华,GUAN,Yi,关奕. EXPRESSION OF P120ctn IN NON-SMALL-CELL LUNG CANCER: A CLINICOPATHOLOGICAL STUDY[J]. 中国癌症研究, 2002, 14(4): 274-278,269. DOI: 10.1007/s11670-002-0060-1 |
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| 作者姓名： | ZHANG Zhi-kun张志坤 LIN Dong林东 WANG En-hua王恩华 GUAN Yi 关奕 |
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| 作者单位： | ZHANG Zhi-kun LIN Dong WANG En-hua GUAN Yi 1Department of Pathology，2Department of Biochemistry，College of Basic Medical Sciences，China Medical University，Shenyang 110001 |
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| 基金项目： | This work was supported by a grant from the Scientific Research Foundation of the Ministry ofEducation of PR China (No. 2002-247). * |
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| 摘 要： | The main characteristics of malignant tumors are invasive growth and the tendency to metastasis. In the process of invasive growth, one of the crucial steps is the detachment of intercellular junctions of tumor cells. Various cell adhesion molecules (CAMs) play an important role in this process. Among the most studied CAMs are the integrins, the selectins, the immunoglobin superfamily, and the cadherins. The cadherins, which are calcium dependent homotypic glycoproteins, form dimeric zipper…
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| 收稿时间： | 2002-07-16 |
| 修稿时间： | 2002-10-25 |
Expression of P120ctn in non-small-cell lung cancer: A clinicopathological study |
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| Zhi-kun Zhang,Dong Lin,En-hua Wang,Yi Guan. Expression of P120ctn in non-small-cell lung cancer: A clinicopathological study[J]. Chinese Journal of Cancer Research, 2002, 14(4): 274-278,269. DOI: 10.1007/s11670-002-0060-1 |
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| Authors: | Zhi-kun Zhang Dong Lin En-hua Wang Yi Guan |
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| Affiliation: | (1) Department of Pathology, College of Basic Medical Sciences, China Medical University, 110001 Shenyang;(2) Department of Biochemistry, College of Basic Medical Sciences, China Medical University, 110001 Shenyang |
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| Abstract: | Objective: To investigate the expression of p120ctn in non-small-cell lung cancer (NSCLC) and its relationshipwith clinicopathological factors and prognosis. Methods: p120ctn expression was tested by immunohistochemistryfor 80 tumors from patients with non-small-cell lung cancer. Correlations were investigated between p120ctnimmunostaining in primary tumors and clinicopathological characteristics and survival. Results: Abnormal expression of p120ctn was found in 68/80(85%) tumors in which 43cases had cytoplasmic staining. Abnormal staining ofp120ctn was related with high TNM stage (P=0.003) andnodal metastasis (P=0.024). However, there was nocorrelation between altered expression with poordifferentiation and histological type. According toKaplan-Meier survival estimate, the expression of p120ctn was related to the poor survival (P=0.015) of patients. ACox regression analysis revealed that p120ctn expressiowas a significant independent factor in the prediction ofsurvival for patients with non-small-cell lung cancer(P=0.008). Conclusion: altered expression of p120ctn wasfound in non-small-cell lung cancers and was correlated with lymph node metastasis and prognosis. From a practical point of view, the expression of p120ctn can be of prognostic value for patients with non-small-cell lung cancer. |
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| Keywords: | p120ctn Non-small-cell lung cancer Immunohistochemistry Prognosis |
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