DIETHYLDITHIOCARBAMATE MAY ENHANCE THE ANTITUMOR EFFECT OF ADRIAMYCIN NANOPARTICLE-LIPIODOL EMULSION

In recent years, various attempts have been made to improve the effect of tumor chemotherapy. One approachof considerable interest is the use of biodegradable nanoparticle or liposome as delivery systems in order to decrease local immune responses and multidrug resistance1, 2]. Our previous studies have showed that the antitumor effect of the superoxide-generating agents, hematoporphyrin derivative combined with laser irradiation and ionizing radiation, can be enhanced by inhibiting the supe…

Diethyldithiocarbamate may enhance the antitumor effect of adriamycin nanoparticle-lipiodol emulsion

Objective: To studied the effect of Diethyldithio-carbamate (DDC) on the antitumor activity of adriamycin (ADM) nanoparticle-lipiodol emulsion. Methods: The SD rats bearing liver carcinoma were divided into six groups and treated by saline, adriamycin, adriamycin nanoparticle-lipiodol emulsion, adriamycin liposome-lipiodol emulsion,DDC plus adriamycin nanoparticle-lipiodol emulsion, DDC plus adriamycin liposome-lipiodol emulsion respectively.The volume of the tumors, tumor growth rate (G%) and life prolonging rate PL% in six groups were determined.Results: The values of the IC50 (mg/ml) of adriamycin were reduced from 18.40 to 0.74 for the resistant cellsSGC7901/CVR, and from 4.00 to 0.32 for the sensitive cells SGC7901/WT by pretreating the tumor cells with DDC. The tumor growth rate (G%) and life prolonging rate PL% increased significantly (P<0.05) in the DDC pretreatedgroups than adriamycin nanoparticle-lipiodol or adriamycin liposome-lipiodol emulsion groups. Conclusion: Theantitumor effect of adriamycin can be enhanced byinhibiting the superoxide dismutase (SOD) in tumor cells by DDC.