| EVALUATION OF THE PROGNOSTIC VALUE OF nm23 GENE EXPRESSION IN BREAST CANCER |
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| 引用本文： | LIU,Hong刘红,MAO,Hui-sheng毛慧生,FU,Xi-lin傅西林,FANG,Zhi-yi方志沂,FENG,Yu-mei冯玉梅,FAN,Yu范宇,LI,Shu-ling李树玲. EVALUATION OF THE PROGNOSTIC VALUE OF nm23 GENE EXPRESSION IN BREAST CANCER[J]. 中国癌症研究, 2002, 14(2): 88-92. DOI: 10.1007/s11670-002-0020-9 |
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| 作者姓名： | LIU Hong刘红 MAO Hui-sheng毛慧生 FU Xi-lin傅西林 FANG Zhi-yi方志沂 FENG Yu-mei冯玉梅 FAN Yu范宇 LI Shu-ling李树玲 |
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| 作者单位： | LIU Hong1，MAO Hui-sheng2，FU Xi-lin2，FANG Zhi-yi1 FENG Yu-mei2，FAN Yu2，LI Shu-ling1 1Department of Breast Diseases，Tianjin Medical University，Cancer Hospital，2Tianjin Cancer Institute，Tianjin 300060 |
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| 基金项目： | This work was supported by the National 9th Five-Year Program of China(No. 96-906-01-13). |
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| 摘 要： | Mortality of breast cancer is almost due to subsequent metastases, but the micrometastasis is difficult to be detected. Early diagnosis of distant metastasis is a key to improve prognosis of breast cancer. The nm23 gene is a putative metastasis suppressor gene originally identified in murine melanoma cells. The purpose of this study was to investigate the relationship between nm23 gene expression (mRNA and protein) and distant metastasis of breast cancer. MATERIALS AND METHODS Pati…
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| 收稿时间： | 2002-02-08 |
| 修稿时间： | 2002-03-28 |
Evaluation of the prognostic value of nm23 gene expression in breast cancer |
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| Hong Liu,Hui-sheng Mao,Xi-lin Fu,Zhi-yi Fang,Yu-mei Feng,Yu Fan,Shu-ling Li. Evaluation of the prognostic value of nm23 gene expression in breast cancer[J]. Chinese Journal of Cancer Research, 2002, 14(2): 88-92. DOI: 10.1007/s11670-002-0020-9 |
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| Authors: | Hong Liu Hui-sheng Mao Xi-lin Fu Zhi-yi Fang Yu-mei Feng Yu Fan Shu-ling Li |
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| Affiliation: | (1) Department of Breast Diseases, Tianjin Medical University, Cancer Hospital, China;(2) Tianjin Cancer Institute, 300060 Tianjin |
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| Abstract: | Objective: To investigate the expression of nm23 gene and evaluate its prognostic value in breast cancer. Methods: nm23 expressions were detected in 101 breast cancer patients (group 1) by immunohistochemistry. RT-PCR and immunohistochemistry were used to measure expressions of nm23 gene in another 68 patients with breast cancer (group 2). Results: nm23 gene expression in group 1 was inversely associated with distant metastasis and lymph node metastasis (P<0.05). In 44 patients with negative lymph node, 9 cases progressed to distant metastasis, 7 of them (77.8%) showed low expression of nm23 gene (P<0.05). In 57 patients with positive lymph node, 24 our of 29 patients who had no distant metastasis (82.8%) expressed nm23 gene at high level (P<0.05). Meanwhile, there were 6 patients with distant metastasis in the group 2, all of thenm expressed nm23 gene mRNA at low level. Conclusion: The results showed that nm23 gene might play an independent role in predicting prognosis of breast cancer. |
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| Keywords: | nm23 gene Breast cancer Prognostic value |
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