| RELATED GENES IN LUNG CANCER TISSUES ASSOCIATED WITH RESIDENTIAL HIGH RADON EXPOSURE |
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| 作者姓名： | XIA Ying夏英 YANG Mei-ying杨梅英 ZHANG Shou-zhi张守志 YE Chang-qing叶常青 |
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| 作者单位： | XIA Ying1*，YANG Mei-ying2，ZHANG Shou-zhi1，YE Chang-qing2 1Laboratory of Industrial Hygiene，Ministry of Public Health，PR China，Beijing 100088; 2Institute of Radiation Medicine，Beijing 100850 |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China (No. 39970235). |
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| 摘 要： | As science and technology have been getting more and more improvement, people begin to pay more attention on their environment, especially the natural radiation. Epidemiological studies on underground miners showed that the inhalation of radon progeny is associated with an increased risk of lung cancer1]. Radon in dwellings is the dominant source of exposure to ionizing radiation in most countries2]. It was assessed that 10%~15% of residential lung cancer may be associated with radon3]. The…
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| 收稿时间： | 26 November 2001 |
| 修稿时间： | 21 March 2002 |
Related genes in lung cancer tissues associated with residential high radon exposure |
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| Ying Xia,Mei-ying Yang,Shou-zhi Zhang,Chang-qing Ye.RELATED GENES IN LUNG CANCER TISSUES ASSOCIATED WITH RESIDENTIAL HIGH RADON EXPOSURE[J].Chinese Journal of Cancer Research,2002,14(2):105-107. |
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| Authors: | Ying Xia Mei-ying Yang Shou-zhi Zhang Chang-qing Ye |
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| Institution: | (1) Laboratory of Industrial Hygiene, Ministry of Public Health, PR China, 100088 Beijing;(2) Institute of Radiation Medicine, 100850 Beijing |
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| Abstract: | Objective: To investigate the related genes in lung cancer tissues associated with residential high radon exposure. Methods: Differentially expressed gene fragments in lung cancer and normal lung tissues were discovered by differential display and reverse Northern blot hybridization method. The fragments positive in lung cancer and negative in normal lung tissue were determined. Results: Seven differential displayed fragments were sequenced. One of them named NA7 is 95% homologous with AI208667 in EAT of Genbank. Another fragment named NG2 is up to 98% homologous with five fragments. The remained one CA1 may be a new gene fragment. Conclusion: 3 gene fragments were discovered from lung cancer and normal lung tissues of high radon exposure resident. |
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| Keywords: | Lung cancer Related genes Differential display Radon exposure |
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