| 苦参素辅助阿德福韦酯治疗慢性乙型肝炎的临床观察 |
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| 引用本文： | 何红娟,许先继,陈康. 苦参素辅助阿德福韦酯治疗慢性乙型肝炎的临床观察[J]. 现代医药卫生, 2010, 26(8): 1132-1133 |
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| 作者姓名： | 何红娟 许先继 陈康 |
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| 作者单位： | 中国海洋石油南海西部公司职工医院内科,广东,湛江,524057 |
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| 摘 要： | 目的:探讨苦参素辅助阿德福韦酯治疗慢性乙型肝炎的疗效.方法:将95例慢性乙肝患者随机分为阿德福韦酯组和联合治疗组,阿德福韦酯组给予阿德福韦酯治疗,联合治疗组给予苦参素和阿德福韦酯治疗,疗程6个月.观察治疗前后两组治疗有效率、生化指标及HBV-DNA转阴率.结果:联合治疗组和阿德福韦酯组有效率分别为85.7%和71.9%,前者的总有效率显著高于后者(P＜0.05).两组治疗前后ALT、AST、γ-GT数据差异均有显著性(P＜0.05).治疗后联合治疗组的ALT和AST均显著低于阿德福韦酯组(P＜0.05),两组间的γ-GT差异无显著性(P＞0.05).两组的ALT、TBTL复常率差异有显著性(P＜0.05),联合治疗组的HBV-DNA转阴例数也显著多于阿德福韦酯组(P＜0.05).结论:苦参素可有效辅助阿德福韦酯治疗慢性乙型肝炎,其疗效要好于阿德福右酯单用.
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| 关 键 词： | 苦参素 阿德福韦酯 慢性乙型肝炎 |
Clinical effect of adefovir dipivoxil and oxymatrine in treatment of chronic hepatitis B |
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| HE Hong-Juan , XU Xian-ji , CHEN Kang. Clinical effect of adefovir dipivoxil and oxymatrine in treatment of chronic hepatitis B[J]. JOURNAL OF MODERN MEDICINE & HEALTH, 2010, 26(8): 1132-1133 |
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| Authors: | HE Hong-Juan XU Xian-ji CHEN Kang |
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| Affiliation: | HE Hong-Juan,XU Xian-Ji,CHEN Kang(Department of Internal Medicine,Staff Hospital of China Off-Shore Oil Nanhai West Corporation,Zhanjiang,Guangdong 524057,China) |
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| Abstract: | Objective:To observed the efficacy of oxymatrine and adefovir dipivoxil in the treatment of chronic hepatitis B.Methods:95 patients with chronic hepatitis B were randomly divided into adefovir dipivoxil treatment group and united treatment groups.They were treated for 6 months.The total effective rate,chemical indicators and HBV-DNA negative rate were detected.Results:The total effective rate of united treatment groups was 85.7%,which was significantly higher than 71.9% of the adefovir dipivoxil group.There... |
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| Keywords: | Oxymatrine Adefovir dipivoxil Chronic hepatitis B |
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