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Activity of cytochrome P450 in children
Authors:V.?A.?Vavilin  author-information"  >  author-information__contact u-icon-before"  >  mailto:drugmet@soramn.ru"   title="  drugmet@soramn.ru"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author,E.?G.?Shchepotina,N.?A.?Manankin,L.?F.?Kaznacheeva,V.?V.?Lyakhovich
Affiliation:(1) Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Russia;(2) First Municipal Children Hospital, Russia;(3) State Medical Academy, Novosibirsk
Abstract:The 6beta-hydroxycortisol/cortisol ratio was measured in 52 children aging 1.1–14.0 years. The maximum increment in this ratio occurred in the age interval of 1.1–2.0 years. During this period, the regression coefficients in the linear (r=0.57; p=0.044) and nonlinear logarithmic models (r=0.56; p=0.049) were similar. At the age of 10–14 years, the examined ratio attained 19.17±17.79.Translated from Byulletenrsquo Eksperimentalrsquonoi Biologii i Meditsiny, Vol. 138, No. 9, pp. 272–274, September, 2004
Keywords:cytochrome P450 3A  activity  age-related changes  polymorphism
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