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Creatine kinase isoenzyme (CK-BB) in combination to prostatic acid phosphatase measured by RIA in the diagnosis of prostatic cancer |
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| Authors: | Dr P R Huber Th Zaugg E Linder V Hagmaier G Rutishauser |
| Institution: | (1) Hormone Laboratory, Department of Gynaecology, Urological Clinic, Kantonsspital Basel, CH-4031 Basel, Switzerland;(2) Urological Clinic, Kantonsspital Basel, CH-4031 Basel, Switzerland;(3) Department of Surgery, Kantonsspital Basel, CH-4031 Basel, Switzerland;(4) Zentrallaboratorium, Kantonsspital Basel, CH-4031 Basel, Switzerland |
| Abstract: | Summary Creatine kinase isoenzyme (CK-BB) measured by mass was used to determine its value in the early diagnosis of prostatic cancer. Sera of patients with prostatic carcinoma of various stages (treated and untreated) were compared to normal male sera and sera of patients with benign hyperplasia of the prostate (BPH) with respect to CK-BB. The sera were simultaneously tested for PAP content. The sensitivity of the CK-BB-RIA was 1.63+/-0.08  g/l and reproducibility in the higher and lower concentration range 7.6% and 10.5%, respectively. CK-BB alone or in combination with PAP is no marker for early detection of prostatic cancer. In individual cases changes occurred similar to those found with a malignant growth of the prostate. |
| Keywords: | Creatine kinase (BB) Prostatic acid phosphatase (PAP) Radioimmunoassay Prostatic cancer Benign prostatic hyperplasia |
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