益气养阴清热活血法治疗早期糖尿病肾病的疗效及对血液流变学的影响

目的观察益气养阴清热活血中药治疗早期糖尿病肾病(DN)的临床疗效。方法筛选临床98例早期糖尿病肾病患者,随机分为研究组52例,对照组46例,2组患者均按照西医临床诊疗指南对早期糖尿病肾病进行常规治疗,研究组患者加用益气养阴清热活血功效的糖肾1号方,2组患者均临床治疗3个月,比较临床疗效、血糖控制情况、肾功能及血液流变学改善情况。结果研究组治疗的总有效率为98.07%,显著高于对照组的89.13%,有统计学意义(P<0.05)。2组患者治疗后FPG、2 h PG、Hb A1c、24 h UAER、Um Alb、SCr均较治疗前明显好转,差异具有统计学意义(P<0.05)。研究组治疗后24 h UAER、Um Alb、SCr与对照组相比,差异具有统计学意义(P<0.05)。研究组治疗后血液流变学指标均较治疗前明显好转,且显著优于对照组,有统计学意义(P<0.05)。结论益气养阴清热活血法治疗早期糖尿病肾病临床疗效确切,对肾脏起到有效的保护作用,能够早期预防DN病程进展。

Effect of tonifying qi-nourishing yin-clearing heat-activating blood therapy for early diabetic nephropathy and its influence on blood rheology

Objective To observe the clinical effect of Tonifying Qi-Nourishing Yin-Clearing Heat-Activating Blood Therapy on the treatment of early diabetic nephropathy（ DN）. Methods 98 cases of DN？ were randomly divided into study group with 52 cases and the control group with 46 cases. The two groups were treated by conventional treatment according to the clinical guidelines of Western Medicine for the diagnosis and treatment of early diabetic nephropathy. The study group was added Tangshen No. 1 which has the effect of tonifying qi,nourishing yin,clearing heat and activating blood. After the clinical treatment for 3 months,the clinical efficacy,blood glucose control,renal function and hemorheology were compared. Results The total effectiveness of study group was 98. 07%,which was significantly higher than 89. 13% in the control group（ P〈0. 05）. The,FPG,2 h PG,Hb A1 c,24 h UAER,Um Alb,SCr of two groups after treatment were significantly improved. The differences were statistically significant（ P〈0. 05）. After24 h treatment,the levels of UAER,Um Alb,SCr of study group were statistically significant compared with those of the control group. The differences were statistically significant（ P〈0. 05）. After treatment,blood rheology indexes of the study group were significantly improved than pre-treatment,which were significantly better than those of the control group. The differences were statistically significant（ P〈0. 05）. Conclusion The therapeutic effect of Tonifying QiNourishing Yin-Clearing Heat-Activating Blood Therapy for early DN is accurate. With protective effect on kidney,it can prevent the early progression of DN.