Decrease in adhesion molecules on polymorphonuclear leukocytes of patients with fibromyalgia |
| |
| Authors: | Ines Kaufmann Gustav Schelling Christoph Eisner Hans Peter Richter Antje Beyer Till Krauseneck Alexander Chouker and Manfred Thiel |
| |
| Institution: | (1) Department of Anesthesiology, Klinikum Gro?hadern, Ludwig-Maximilians-University, Marchioninistrasse 15, 81366 Munich, Germany;(2) Department of Psychiatry, Ludwig-Maximilians-University, 81366 Munich, Germany |
| |
| Abstract: | Fibromyalgia (FM) is a chronic widespread pain condition in highly stressed humans. Because stress is known to modulate adhesion
molecule expression, we determined L-selectin (CD62L) and β2-integrin (CD11b/CD18) expression on the surface of polymorphonuclear leukocytes in 22 patients with FM. As compared to age
and sex-matched healthy controls, FM patients showed a significantly decreased expression of CD62L (p < 0.01) and CD11b/CD18 (p < 0.05) on polymorphonuclear leukocytes. These changes might lower the rate of polymorphonuclear leukocyte migration to sites
of inflammation and thereby compromise defense against infections and pain control. |
| |
| Keywords: | Fibromyalgia Polymorphonuclear leukocyte Adhesion molecule L-selectin (CD62L)" target="_blank">L-selectin (CD62L) β 2-integrin (CD11b/CD18) |
| 本文献已被 SpringerLink 等数据库收录！ |
