HAEMODYNAMIC EFFECTS OF LONG-TERM ENDOTHELIN INFUSION IN CONSCIOUS SHEEP |
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| Authors: | Amanda F. Reid,David G. Parkes,John P. Coghlan,Bruce A. Scoggins &dagger ,Judith A. Whitworth |
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| Affiliation: | Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia. |
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| Abstract: | 1. Synthetic human endothelin-1 was infused intravenously at 15 micrograms/h for 24 h to examine its cardiovascular actions in five conscious sheep. 2. Endothelin produced a maximum increase in mean arterial pressure (MAP) of +8 mmHg at 8 h, with an increase in calculated total peripheral resistance (CTPR) of +2.6 mmHg/L per min, whilst cardiac output (CO) was unchanged. At 24 h MAP was not significantly elevated, however CTPR had increased by +2.8 mmHg/L per min and CO had decreased by 0.9 L/min. 3. This study shows that long-term administration of endothelin produces sustained arterial vasoconstriction in sheep. |
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| Keywords: | blood pressure cardiac output endothelin sheep |
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