Integrated MEG and fMRI Model: Synthesis and Analysis |
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Authors: | Abbas?Babajani Mohammad-Hossein?Nekooei Email author" target="_blank">Hamid?Soltanian-ZadehEmail author |
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Institution: | (1) Control and Intelligent Processing Center of Excellence, Electrical and Computer Engineering Department, University of Tehran, Tehran, Iran;(2) Image Analysis Lab., Radiology Department, Henry Ford Health System, One Ford Place, 2F, Detroit, MI 48202, USA |
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Abstract: | Summary: An integrated model for magnetoencephalography (MEG) and functional Magnetic Resonance Imaging (fMRI) is proposed. In the
model, the neural activity is related to the Post Synaptic Potentials (PSPs) which is common link between MEG and fMRI. Each
PSP is modeled by the direction and strength of its current flow which are treated as random variables. The overall neural
activity in each voxel is used for equivalent current dipole in MEG and as input of extended Balloon model in fMRI. The proposed
model shows the possibility of detecting activation by fMRI in a voxel while the voxel is silent for MEG and vice versa. Parameters
of the model can illustrate situations like closed field due to non-pyramidal cells, canceling effect of inhibitory PSP on
excitatory PSP, and effect of synchronicity. In addition, the model shows that the crosstalk from neural activities of the
adjacent voxels in fMRI may result in the detection of activations in these voxels that contain no neural activities. The
proposed model is instrumental in evaluating and comparing different analysis methods of MEG and fMRI. It is also useful in
characterizing the upcoming combined methods for simultaneous analysis of MEG and fMRI.
This work was supported in part by the Research Council of the
University of Tehran, Tehran, Iran. The authors would like to thank Dr.
John Moran from the Neurology Department, Henry Ford Health
System, Detroit, Michigan, USA for his helpful discussions and kind
assistance. |
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Keywords: | Functional Magnetic Resonance Imaging (fMRI) Magnetoencephalography (MEG) Extended balloon model Integrated model Post Synaptic Potential (PSP) |
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