胃癌根治术后复发转移临床相关因素分析

目的 探讨胃癌术后复发转移时间及危险因素.方法 回顾性分析2001年1月至2004年l 2月间天津医科大学附属肿瘤医院收治的141例行胃癌根治术后发生复发转移患者的临床病理资料,分析可能影响胃癌术后复发的临床病理因素.结果 术后1、2、3、5年的累积复发率分别为58.2%(82/141)、80.1%(113/141)、89.4%(126/141)、97.9%(138/141).多因素分析显示:肿瘤大小、浸润深度、淋巴结转移是影响胃癌根治术后复发转移发生的独立因素(P值分别=0.017、0.003、0.000),浸润深度、淋巴结转移、肿瘤分化程度是影响胃癌根治术后早期复发转移的独立危险因素(P值分别=0.042、0.000、0.039).结论 肿瘤大小、浸润深度、淋巴结转移是预测胃癌根治术后复发转移发生的独立危险因素;胃癌术后复发转移大部分发生在术后2年内,浸润深度、淋巴结转移及肿瘤分化程度是预测胃癌根治术后早期复发转移的独立危险因素.

Abstract：

Objective To explore the occurance and risk factors of recurrence and metastasis of gastric cancer after gastrectomy.Methods From January 2001 to December 2004, the clinic pathological data of 141 patients with recurrence and metastasis after radical gastrectomy in Tianjin Medical University Cancer Institute and Hospital were analyzed retrospectively.The possible clinic pathological factors which may affect tumor recurrence were analyzed.Results After the surgery, the 1, 2, 3 and 5-year cumulative recurrence rates were 58.2%(82/141) 、80.1%(113/141)、89.4%(126/141) 、97.9 % (138/141)respectively.The results of multivariate analysis indicated that the tumor size,invasive depth, lymph node metastasis were independent factors which affected recurrence and metastasis after radical gastrectomy (P = 0.017, 0.003, 0.000).Invasive depth, lymph node metastasis and tumor differentiation degree were independent factors which affected early recurrence and metastasis after radical gastrectomy (P=0.042, 0.000, 0.039).Conclusions The tumor size,invasive depth, lymph node metastasis are the independent risk factors to predict the recurrence and metastasis after radical gastrectomy.Most of the recurrences and metastasis is found within 2 years after radical gastrectomy.Invasive depth, lymph node metastasis and tumor differentiation degree are the independent factors to predict early recurrence after radical gastrectomy.

The analysis of clinical related factors of recurrence and metastasis of gastric cancer after radical gastrectomy

Objective To explore the occurance and risk factors of recurrence and metastasis of gastric cancer after gastrectomy.Methods From January 2001 to December 2004, the clinic pathological data of 141 patients with recurrence and metastasis after radical gastrectomy in Tianjin Medical University Cancer Institute and Hospital were analyzed retrospectively.The possible clinic pathological factors which may affect tumor recurrence were analyzed.Results After the surgery, the 1, 2, 3 and 5-year cumulative recurrence rates were 58.2%(82/141) 、80.1%(113/141)、89.4%(126/141) 、97.9 % (138/141)respectively.The results of multivariate analysis indicated that the tumor size,invasive depth, lymph node metastasis were independent factors which affected recurrence and metastasis after radical gastrectomy (P = 0.017, 0.003, 0.000).Invasive depth, lymph node metastasis and tumor differentiation degree were independent factors which affected early recurrence and metastasis after radical gastrectomy (P=0.042, 0.000, 0.039).Conclusions The tumor size,invasive depth, lymph node metastasis are the independent risk factors to predict the recurrence and metastasis after radical gastrectomy.Most of the recurrences and metastasis is found within 2 years after radical gastrectomy.Invasive depth, lymph node metastasis and tumor differentiation degree are the independent factors to predict early recurrence after radical gastrectomy.