珍珠梅对亚硝酸钠和四氯化碳所致肝损伤的保护作用

目的 ]研究珍珠梅乙酸乙酯提取物对亚硝酸钠清除率和大鼠血清谷草转氨酶、琥珀酸脱氢酶的影响 .方法 ]在体外测定珍珠梅乙酸乙酯提取物作用下亚硝酸钠清除率的变化 ,在四氯化碳所致急性肝损伤大鼠上测定谷丙转氨酶、琥珀酸脱氢酶活性 ,在小鼠肝匀浆中测定脂质过氧化的产物丙二醛 .结果 ]珍珠梅乙酸乙酯提取物在体外对亚硝酸钠有明显的清除作用 ,能抑制肝匀浆中脂质过氧化产物丙二醛的产生 ;在体内能显著降低由于四氯化碳肝损伤所致的大鼠血清谷丙转氨酶的升高 ,明显回升肝线粒体琥珀酸脱氢酶活性的降低 .结论 ]珍珠梅乙酸乙酯提取物对亚硝酸钠、四氯化碳所致的肝损伤具有保护作用 .

Protective effects of Sorbaria Sorbifolia extract on ethyl acetate and carbon tetrachloride-induced liver damage in rats

OBJECTIVE?To study the effects of the Sorbaria Sorbifolia extract for clearance rate of ethyl acetate, glutaminate-pyruvate transaminase(GPT) and succinate dehydrogenase(SD) in rats.?METHODS?The injury of rat liver was induced by ethyl acetate and carbon tetrachloride. It was detected from serum by colorimetric method in vitro that the clearance rate of ethyl natriumacetate, activity of GPT and SD and the content of liver malondiadehyde in mice.?RESULTS?The Sorbaria Sorbifolia extract increased significantly clearance rate of ethyl acetate in rats in vitro, reduced the content of liver malondiadehyde in mice damaged by carton tetrachloride and the activity of GPT in vivo and increase the activity of SD of liver mitrochondia in rats damaged by carbaon tetrachloride.?CONCLUSION? The Sorbaria Sorbifolia extract has protective effects for ethyl acetate and carton tetrachloride-induced liver damage in rats.