肾综合征出血热危险因素病例对照的非条件Logistic回归分析

作者于1987年10月至1989年1月在西安市未央区对98例肾综合征出血热(HFRS)病例进行了病例对照研究。成组资料分析及非条件Logistic回归模型分析的结果表明,皮肤破损、野外劳动、吃过鼠粪尿污染过的食物、吃过未加热的剩饭菜及口腔粘膜破损均为本病的危险因素,非条件Logistic回归分析上述危险因素的比值比分别为2.80,2.06,2.01,2.33及2.68,且均有统计学意义。分层分析表明,吃鼠粪尿污染过的食物和口腔粘膜破损两因素可能有协同作用,野外劳动中经破损皮收和经口感染可能为疫区人群感染HFRS的主要途径。

Case-control Study on Risk Factors of Hcmorrhagic Fever with Renal Syndrome

A case-control study method was used to investigate the nsk factors of Hemorrhagic Fever with Renal Syndrome (HFRS) in the suburbs of Xi an from October 1987 to January 1989. The results of single variable analysis and unconditional Logistic regression model analysis indicate that the main risk factors of HFRS infection are skin damage, farmwork, food contaminated with excrement and, or urine of rodents, oral mucosa damage and consumption of unhcated leftovers. By unconditional Logistic regression model analysis, the ORs of the risk factors mentioned above are 2.80, 2.06, 2.01, 2.33 arid 2.68 respectively, and the selected variablity have statistical significance. The results of stratified analysis show that the two variables of food contaminated with excrement and/or urine of rodents, and oral mucosa damage may be co-determinants. It is suggested that the main routes of transmission of HFRS in the endemic area may be skin damage in the course of farmwork, and peroral infection.