| 瘦素对人脐静脉内皮细胞血管内皮生长因子表达的影响 |
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| 引用本文： | 王绪明,朱大和. 瘦素对人脐静脉内皮细胞血管内皮生长因子表达的影响[J]. 临床心血管病杂志, 2005, 21(9): 534-536 |
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| 作者姓名： | 王绪明 朱大和 |
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| 作者单位： | 华中科技大学同济医学院基础医学院病理学系,武汉,430030;华中科技大学同济医学院基础医学院病理学系,武汉,430030 |
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| 摘 要： | 目的:探讨瘦素对人脐静脉内皮细胞(HUVECs)血管内皮生长因子(VEGF)表达的影响。方法:用不同浓度的瘦素刺激原代培养的HUVECs,检测HUVECs表达VEGF的情况。结果:在相同作用时间下,随着瘦素浓度的升高,VEGF蛋白及VEGF mRNA的表达也随之升高,经统计学检验有相关性;在相同瘦素浓度下, 随着作用时间的延长,VEGF蛋白及VEGFmRNA的表达也随之升高,且有相关性。结论:瘦素可以刺激HU- VECs表达VEGF而且呈时间和剂量相关性。
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| 关 键 词： | 动脉粥样硬化 瘦素 血管内皮生长因子 |
| 文章编号： | 1001-1439(2005)09-0534-03 |
| 修稿时间： | 2005-07-06 |
Effect of leptin on VEGF expression in human umbilical vein endothelial cells |
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| WANG Xuming,ZHU Dahe. Effect of leptin on VEGF expression in human umbilical vein endothelial cells[J]. Journal of Clinical Cardiology, 2005, 21(9): 534-536 |
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| Authors: | WANG Xuming ZHU Dahe |
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| Abstract: | Objective:To investigate the effect of leptin on the expression of VEGF in cultured human umbilical vein endothelial cells (HUVECs). Method:The leptins in different concentrations were used to stimulate the primary cultured HUVECs and then detected the level that the HUVECs express the VEGF. Result:With the same time, the expression of VEGF protein and VEGF mRNA increased when the level of leptin increased; meanwhile, with the same concentration of leptin, the expression of VEGF protein and VEGF mRNA increased when the time extended. Both are significant when they are analyzed by the statistics. Conclusion: The expression of VEGF is concerned with the level of leptin and the time that the leptin acts on the HUVECs. |
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| Keywords: | Atherosclerotic Leptin Vascular endothelium growth factors |
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