不同粉碎度野生西洋参人参皂苷Rb1的体外溶出度研究

目的 采用体外溶出法考察野生西洋参细粉、极细粉与超微粉人参皂苷Rb₁的溶出速率与溶出度。方法 按2010年版《中国药典》规定进行不同粉碎度野生西洋参粉体外溶出度试验，绘制溶出曲线，考察不同粉碎度粉末的体外溶出行为及释药机制。结果 前10 min，野生西洋参中人参皂苷Rb₁的溶出速率为极细粉>细粉>超微粉，10 min后超微粉的溶出率最大，极细粉的溶出次之，而细粉溶出最慢。结论 野生西洋参粉中人参皂苷Rb₁的溶出速率与粉末本身的粒径和浸润有关，在粉末浸润后，超微粉的溶出最快。

In vitro dissolution rate of ginsenoside Rb1 in superfine powder of wild Panacis Quinquefolii Radix

Objective Using in vitro dissolution experiment to study the dissolution rate of ginsenoside Rb₁ in fine powder, very fine powder, and superfine powder of wild Panacis Quinquefolii Radix . Methods According to Chinese Pharmacopoeia 2010, the in vitro dissolution test of wild Panacis Quinquefolii Radix powder with different comminution degrees was carried out, the dissolution curves were plotted, and the in vitro dissolving behavior and drug release mechanism were investigated. Results The dissolution rate of very fine powder is higher than that of fine powder and superfine powder at the first 10 min. After 10 min, the dissolution rate of superfine powder is the highest, then those of the very fine powder and the fine powder were the lowest. Conclusion The dissolution rate of ginsenoside Rb₁ in wild Panacis Quinquefolii Radix powder is related with the powder particle size and infiltration, the dissolution rate of the superfine powder is the highest.