注射用氯诺昔康与注射用头孢甲肟在氯化钠注射液中配伍稳定性研究

目的 考察注射用氯诺昔康与头孢甲肟在0.9%氯化钠注射液中的配伍稳定性，为临床合理用药提供理论依据。方法 在室温条件下，采用HPLC法测定8 h内配伍溶液中氯诺昔康、头孢甲肟的变化，并观察和检测外观、pH值变化，结果 配伍溶液在8 h内氯诺昔康的质量分数未见明显变化，但头孢甲肟质量分数不断下降，8 h后为95.3%。pH值随时间变化逐渐降低，溶液颜色随时间变化逐渐加深。结论 在室温条件下，注射用氯诺昔康与注射用头孢甲肟在0.9%氯化钠注射液中2 h内保持稳定，可配伍使用。

Compatible stability of Lornoxicam for injection and Cefmenoxime for injection in 0.9% sodium chloride injection

Objective To study the stability of compatibility of Lornoxicam for injection and Cefmenoxime for injection in 0.9% sodium chloride injection to supply the evidence for clinical rational administration. Methods HPLC method was carried out to study the content change of cefmenoxime and lornoxicam in 0.9% sodium chloride injection under the room temperature. The appearance of the solution was observed and its pH value was determined. Results No significant difference was found in the content of lornoxicam within 8 h, but the contents of cefmenoxime declined with 95.3% of the initial concentration during 8 h. The pH value decreased and the color gradually deepened as time went on. Conclusion The mixture of cefmenoxime with lornoxicam in 0.9% sodium chloride injection can be used under the room temperature, but must be injected within 2 h.