联合用药的药物相互作用及研究方法

随着人们对于疾病的认识越来越深入，联合用药得到越来越普遍的使用，同时所产生的药物间的相互作用也越来越受到关注。联合用药可能通过影响与药物吸收、分布、代谢、排泄等相关的酶、转运体等，以改变药物的药代属性（生物利用度、分布特性等），调节体内动态药效物质组的构成，改变药物的药效（协同作用、拮抗作用、毒副作用等），从而对药物的有效性、安全性产生影响。从联合用药对药物吸收与代谢的影响这两方面来阐述联合用药的研究近况，为联合用药的基础研究以及临床应用的安全有效提供参考。

Drug interactions and research methods of drug combination

As people increasingly in-depth understanding of the disease, drug combination has been more widely used, and the generated interactions of drug combination have attracted more and more attention. Drug combination may impact the enzymes and transporters associated with drug absorption, distribution, metabolism, and excretion, so as to change the drug pharmacokinetics properties (bioavailability, distribution characteristics, etc), regulate the dynamic effective substance groups constituted in body, change the drug effect (synergism, antagonism, side effects, etc), and impact the efficacy and safety of drugs. Now this article explained the current research status of drug combination by summarizing the effects of drug combination on absorption and metabolism of drugs, in order to provide some reference to basic research and clinical application about drug combination.