女贞子及其有效成分的保肝作用研究进展

女贞子具有保肝的药理作用，已经证实齐墩果酸、红景天苷、女贞子多糖等化合物是其保肝的有效成分。女贞子提取物及其有效成分能对抗多种化学性肝损伤、对抗免疫性或缺血再灌注性肝损伤以及抗肝纤维化，其中齐墩果酸的保肝作用被研究得最为广泛而深入；抗氧化应激、抗炎、抑制肝星状细胞增殖和活化、促进其凋亡以及肝细胞再生可能是它们共同的保肝机制。综述了女贞子粗提物、女贞子多糖和红景天苷保肝作用的研究进展。

Research advances on hepatoprotective effects of Ligustri Lucidi Fructus and its active constituents

Ligustri Lucidi Fructus has hepatoprotective effect. It has confirmed that oleanolic acid, salidroside, and polysaccharides are hepatoprotective constituents of Ligustri Lucidi Fructus. The extracts and active constituents from Ligustri Lucidi Fructus counteract many chemicals-induced liver injuries, immunological liver injury, hepatic ischemic/reperfusion injury, and liver fibrosis. Therein the hepatoprotective effect of oleanolic acid is studied most extensively and deeply. Anti-oxidative stress, anti-inflammation, inhibition on the proliferation and activation of hepatic stellate cells, promoting apoptosis of hepatic stellate cells, and hepatocyte regeneration may be their common hepatoprotective mechanism. This paper reviews the research advances on hepatoprotective effects of crude extracts from Ligustri Lucidi Fructus, polysaccharides from Ligustri Lucidi Fructus, and salidroside.