固肾1号对膜性肾小球肾炎的治疗作用

目的 观察固肾1号对膜性肾小球肾炎的影响，并探讨其可能的作用机制。方法 采用家兔C-BSA膜性肾炎模型和大鼠主动Heymann模型，观察固肾1号对尿蛋白定量、血液生化、肾脏系数、肾脏病理的影响。结果 固肾1号能显著降低（24 h）尿蛋白定量，降低血清尿素氮（BUN）、肌酐（Cr）水平，升高血清总蛋白（Tp）、白蛋白（Alb）水平，并能降低肾脏系数，减轻肾脏病变。结论 固肾1号对膜性肾小球肾炎有明显的防治作用。

Therapeutic effect of Gushen 1 on membraneous glomerulo nephritis

Objective To investigate the effect of Gushen 1 on the membranous glomerulonephritis and detect its possible mechanisms. Methods C-BSA membranous nephritis of rabbitss induced by administration of an exogenous cationic antigen and active Heymann nephritis of rats induced by immunization with renal cortex were used to observe the therapeutic effect of Gushen 1 on urine protein, blood biochemistry, kidney index, and kidney pathology. Results Gushen 1 could significantly reduce 24 h surine protein, serum urea nitrogen, and serum creatinine, while increase the levels of serum total protein and albumin. A significant reducing of renal index and improvement of kidney pathology were observed in the group of Gushen1compared to the model group. Conclusion It is obvious that Gushen 1 could improve the kidney pathology and be used for the treatment of membranous glomerulonephritis.