参苓白术散辅助西药治疗小儿秋季腹泻疗效的Meta分析

目的 运用Meta分析方法系统评价参苓白术散辅助西药治疗小儿秋季腹泻的临床疗效。方法 计算机检索Pubmed、中国期刊全文数据库（CNKI）、中文科技期刊全文数据库（维普）、万方数字化期刊全文库等数据库，对纳入的随机对照试验文献进行质量评价，并采用RevMan 5.0软件进行Meta分析。结局指标为总有效率、止泻时间、退热时间和止吐时间。结果 纳入9个随机对照试验，共665例患儿。Meta分析结果显示，参苓白术散辅助西药的临床总有效率优势比（OR）=4.98，95%置信区间（CI）（3.03，8.19），P<0.01；止泻时间加权均数差（WMD）=-26.16，95%CI（-31.26，-21.05）P<0.01；退热时间WMD=-15.26，95%CI（-19.17，-11.34），P<0.01；止吐时间WMD=-17.45，95%CI（-27.33，-7.57），P<0.01，表明治疗组疗效均优于对照组。结论 参苓白术散辅助西药治疗小儿秋季腹泻疗效较单独西药治疗效果好。

Meta analysis on clinical efficiency of Shenling Baizhu Powder assisted with Western medicine in treatment of autumnal infantile diarrhea

Objective To evaluate the clinical efficiency of Shenling Baizhu Powder assisted with Western medicine in the treatment of autumnal infantile diarrhea by Meta analysis. Methods Pubmed, China Journal Full-text Database (CNKI), Chinese Science and Technology Journal Full-text Database (VIP), Wangfang Database, etc were retrieved by computer, and the quality assessment of qualified random control trials was evaluated. Meta analysis was carried out by RevMan 5.0 software. The outcomes included total effective rate, antidiarrheic time, defervescence time, and antiemetic time. Results Nine trials involving 665 patients were included in the study. Meta analysis showed that total effective rate: odds ratio (OR) = 4.98, 95% confidence interval (CI) (3.03, 8.19), P < 0.01; antidiarrheic time: weighted mean difference (WMD) = -26.16, 95%CI (-31.26, -21.05), P < 0.01; defervescence time: WMD = -15.26, 95%CI (-19.17, -11.34), P < 0.01; antiemetic time: WMD = -17.45, 95%CI (-27.33, -7.57), P < 0.01. The efficacy of the treatment group was better than that in the control group. Conclusion Compared with Western medicine alone, Shenling Baizhu Powder assisted with Western medicine has the certain advantages in the treatment of autumnal infantile diarrhea.