人参健心胶囊对胰岛素抵抗大鼠内皮的保护作用

目的 观察人参健心胶囊对胰岛素抵抗（IR）大鼠内皮的保护作用。方法 通过高脂膳食建立胰岛素抵抗Wistar大鼠模型，分为人参健心胶囊高、低剂量组，二甲双胍治疗组，模型组，并设立正常对照组，疗程6周。以李氏胰岛素敏感指数（ISI）评价胰岛素抵抗，对照各治疗组与模型对照组内皮素-1（ET-1）、一氧化氮（NO）指标，光镜下观察主动脉血管内皮形态。结果 人参健心胶囊高、低剂量治疗组和二甲双胍治疗组治疗后胰岛素水平明显降低、胰岛素敏感指数明显升高，NO明显升高，ET-1明显降低。光镜下观察人参健心高剂量组、二甲双胍组内皮结构基本正常，模型组内皮损伤严重。结论 人参健心胶囊可以改善胰岛素抵抗大鼠的胰岛素抵抗状态，对血管内皮具有保护作用。

Protective effects of Renshen Jianxin Capsule on endothelium of rats with insulin resistance

Objective To explore the protective effects of Renshen Jianxin Capsule (RJC) on the endothelium of rats with insulin resistance (IR). Methods The model of IR was established by feeding high fat laboratory diet. The model rats were divided into several groups: control, model, metformin, high- and low-dose RJC groups, six weeks as a course of treatment. IR was evaluated using Lee insulin sensitivity index (ISI), the levels of NO and endothelin-1 (ET-1) in blood were compared, and the endothelial cells in slice aortic arch were observed. Results In metformin, high- and low-dose RJC groups, the levels of insulin and ET-1 decreased, and the ISI and NO level increased significantly. The endothelium of slice aortic arch in the model group was hurt heavily, while the endothelium of high-dose RJC and metformin groups is generally normal. Conclusion RJC could improve IR and protect blood vessel endothelium.