中药调控细胞色素C的研究进展

目前,心血管疾病、癌症、败血症、脑组织损伤、糖尿病和神经性的疾病在全球的发病率非常高,在这些疾病中细胞色素C(cytochrome C,Cyt-C)均表现出不同程度的代谢紊乱。许多中药提取物、有效部位和化学成分对这些疾病有良好的治疗作用和较小的副作用。中药主要是通过影响疾病相关组织或细胞线粒体内的Cyt-C的产生或释放,调控相应靶细胞的凋亡,进而防治相应的疾病。查阅近年来的相关文献报道,综述了通过调控线粒体通路Cyt-C实现治疗疾病的中药提取物、有效部位和化学成分,希望能提高对中药在防病治病中作用机制的认识。

Research progress on traditional Chinese medicine for controlling cytochrome C

At present, cardiovascular disease, cancer, sepsis, damage of brain tissue, diabetes and neurological diseases have high incidence worldwide, cytochrome C (Cyt-C) shows different degrees of metabolism disorders in these diseases. Many herbal extracts, effective fractions and chemical constituents have a better therapeutic effect and less side effects in treatment of these diseases. Traditional Chinese medicine regulate corresponding target cells apoptosis, and corresponding prevent and cure the diseases, mainly by influencing the produce or release of Cyt-C of diseases related tissue or cell mitochondria. According to the relevant literature in recent years, we reviewed the herbal extracts, effective fractions and chemical constituents by regulating Cyt-C for diseases treatment, hoping to a better understanding on the mechanism of traditional Chinese medicine in the disease prevention.