| 长沙地区汉族人群apoB基因多态性与脑梗死的关系研究 |
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| 引用本文： | 刘宝琼,张乐,杨期东,胡中扬,许宏伟,杜小平,周艳宏,刘运海,夏健.长沙地区汉族人群apoB基因多态性与脑梗死的关系研究[J].脑与神经疾病杂志,2009,17(1). |
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| 作者姓名： | 刘宝琼 张乐 杨期东 胡中扬 许宏伟 杜小平 周艳宏 刘运海 夏健 |
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| 作者单位： | 中南大学湘雅医院神经内科,长沙,410008 |
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| 摘 要： | 目的探讨湖南长沙地区汉族人群载脂蛋白B(apolipoprotein B,apoB)G12669A、C7673T多态性与脑梗死的关系。方法采用聚合酶链反应-限制性片段长度多态性分析法分别检测130例脑梗死患者和100例正常对照的apoB基因G12669A、C7673T多态等位基因频率。结果湖南长沙地区汉族人群存在apoB基因G12669A、C7673T多态性,脑梗死组中apoB基因G12669A、C7673T多态等位基因频率G/A为0.904/0.096,C/T为0.881/0.119,在正常对照G/A为0.955/0.045,C/T为0.960/0.040;脑梗死组apoB基因G12669A多态A等位基因频率及C7673T多态T等位基因频率均显高于正常对照组(P<0.05,P<0.01)。结论apoB G12669A多态A等位基因可能是湖南长沙地区汉族人群脑梗死发病的遗传易感因素。
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| 关 键 词： | 脑梗死 载脂蛋白B 基因多态性 |
Relationship between single nucleotide polymorphisms of apolipoprotein B and cerebral infarction in Han population of Changsha area |
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| LIU Bao-qiong,ZHANG Le,YANG Qi-dong,HU Zhong-yang,XU Hong-wei,DU Xiao-ping,ZHOU Yan-hong,LIU Yun-hai,XIA Jian.Relationship between single nucleotide polymorphisms of apolipoprotein B and cerebral infarction in Han population of Changsha area[J].Journal of Brain and Nervous Diseases,2009,17(1). |
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| Authors: | LIU Bao-qiong ZHANG Le YANG Qi-dong HU Zhong-yang XU Hong-wei DU Xiao-ping ZHOU Yan-hong LIU Yun-hai XIA Jian |
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| Institution: | LIU Bao-qiong,ZHANG Le,YANG Qi-dong,HU Zhong-yang,XU Hong-wei,DU Xiao-ping,ZHOU Yan-hong,LIU Yun-hai,XIA Jian. Department of Neurology,Xiangya Hospital,Central,South university,Changsha 410008,China |
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| Abstract: | Objective To study the relationship between apolipoprotein B (apoB)G12669A、C7673T polymorphisms and cerebral infarction in Han population of Changsha area in China.Methods ApoB gene G12669A and C7673T polyfmorphisms were determined by Polymerase Chain Restriction Fragment Length Polymorphism (PCR-PFLP) in 130 patients with cerebral infarction and 100 healthy controls. Results G12669A and C7673T polymorphisms of apoB gene existed among Han population of Changsha area in China,with the allele frequencies 0.90... |
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| Keywords: | cerebral infarction apolipoprotein B genetic polymorphism |
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