深圳市广州管圆线虫疫源地调查

目的了解深圳市广州管圆线虫疫源地的分布以及中间宿主和终末宿主的种类和生态，同时探明深圳市广州管圆线虫的主要传播途径及其流行特征。方法在深圳12个不同生态环境地调查广州管圆线虫不同宿主分布和感染情况，采用匀浆沉淀镜检法对各调查点捕获的中间宿主进行解剖，以确定中间宿主的感染率和感染度。用鼠笼捕获鼠类，解剖鼠体，在鼠心脏和肺动脉血管寻找广州管圆线虫成虫，从野生螺体内分离的广州管圆线虫幼虫进行实验室广州管圆线虫生活史的循环，完成实验室生活史的循环来证实现场调查的结论。结果在12个调查点中有4个区域发现褐云玛瑙螺阳性，分布在深圳西南部，感染率平均为31％，螺的感染度与体重相关，螺体重大于55g个体平均感染度显著性的高于小于55g的个体（P〈0．05）；阳性螺区域终末宿主褐家鼠和黄胸鼠均有感染，感染率平均为12％，雌鼠的感染率显著性的高于雄鼠（P〈0．01）。结论深圳市存在广州管圆线虫自然疫源地，深圳存在散发广州管圆线虫病人的主要原因。

Survey of infective loci of Angiostrongylus cantonesis in Shenzhen area of Zhujiang Delta in China

Objective To understand the distribution of natural infectious focus of human Angiostrongylus cantonesis in Shenzen and identify the species and ecology of intermidiate host and final host of Angiostrongylus cantonesis as well as its prevalent features and transmission routes. Methods The infecton rate and density of Angiostrongylus cantonesis in different hosts in 12 different ecology areas in Shenzen were investigated by microscopy of snails . Wild mice were captured and Angiostrongylus cantonesis were detected. The life cycle of Angiostrongylus cantonesis were observed in laboratory to verify the results obtained in the field. Results Positive Achatina fulica, was identified in 4 of the 12 districts surveyed, most in the southeast part of Shenzhen with a average infection rate of 31%. Rattus andersoni and Achatina fulica extensively distributed in shrub areas in Shenzhen, where the climate, humidity and vegetation suitable for breeding of Achatina fulica were all infected with Angiostrongylus cantonesis with a mean infection rate of 12% and the infeection rate the female rats was higher than that of the males (P<0.01). The infectiosity was associated with body weight of the snails, the infectiosity was higher in snails with body weight over 55g than those with less body weight (P<0.05) Conclusion There were natural infectious foci of Angiostrongylus cantonesis in Shenzhen that is the main cause of sporadic distribution of patients infected with Angiostrongylus cantonesis .