Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters |
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| Authors: | Chiranjib Pal Mousumi Raha Anirban Basu Keshab Chandra Roy Anasuya Gupta Monidipa Ghosh Niranjan Prasad Sahu Sukdeb Banerjee Nirup Bikash Mandal Santu Bandyopadhyay |
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| Affiliation: | Immunology Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata-700 032, India. |
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| Abstract: | 2-(2"-Dichloroacetamidobenzyl)-3-(3'-indolylquinoline), designated indolylquinoline derivative A, reduced the splenic and the liver parasite burdens by >93.0% in Leishmania donovani-infected hamsters, whereas sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%. Complete clearance of parasitemia from the livers and spleens was noticed when infected animals received indolylquinoline derivative A plus SAG, suggesting that indolylquinoline derivative A has potential as a new agent for sole or conjunctive therapy for leishmaniasis. |
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